SQ between Squeezelite vs MPD

[Miss Sissy Princess]

But before that, I would like to know if somebody else also notice the SQ difference between MPD vs Squeezelite under Moode ? Or I'm just getting crazier due to this pandemic

If you can reliably hear a SQ difference in a level-matched blind test, then there really is a difference.  

Hearing subtle SQ differences that don't really exist isn't a sign you're crazy.  It's a sign you're human. 

It's like asking "Is this moving, or am I crazy?"